Blood in urine diagnosis

Diagnosing and Monitoring Carcinoid Syndrome

Chromogranin A(CgA) TestingAdding to the challenge is the fact that carcinoid syndrome is a fairly rare condition. Your doctor might not have been looking for carcinoid syndrome when your symptoms first started. That's why, if you've gotten to the point of getting your carcinoid syndrome diagnosed, you are more fortunate than many patients. You're well on your way toward helping to manage carcinoid syndrome.

There are several tests that your doctor can use to diagnose carcinoid syndrome and to monitor it once it has been diagnosed. It's important to be monitored regularly for changes in your symptoms or test results. Regular doctor visits will also help you get the best possible outcome.

On this page, you'll learn about:

*OctreoScan® is a registered trademark of Mallinckrodt, Inc.

The Chromogranin A (CgA) blood test is a good marker to help detect and monitor the activity of carcinoid tumors in general. This includes carcinoid tumors that secrete certain hormones that are associated with carcinoid syndrome as well as carcinoid tumors that do not cause carcinoid syndrome. Elevated levels of CgA are found in 80-100% of patients with carcinoid tumors.

5-HIAA TestCgA is a protein found in carcinoid tumor cells, and it may be secreted into the blood. A blood sample is taken, and the level of CgA in the bloodstream is determined.

A CgA test is fast, easy to perform, and accurate. However, increased levels of this marker may also be caused by other factors such as renal failure, chronic atrophic gastritis or the use of proton-pump inhibitors.

How the Test Is Done

A blood sample is taken and then tested with a CgA-specific enzyme-conjugated antibody. The antibody and enzyme bind the CgA protein as a "sandwich"—the purpose of the antibodies is to bind with the CgA protein, while the enzymes produce color. The intensity of the color is proportional to the specimen's CgA concentration. The CgA test uses CgA-specific antibodies to measure the level of CgA in the body.

Measurements may vary with meal consumption so patients are required to fast before a CgA test. CgA tests are performed every 3 to 6 months.

5-HIAA testing is a 24-hour urine test that is specific to carcinoid tumors—levels of 5-HIAA are not elevated with other types of tumors. This test is the most common biochemical test for carcinoid tumors associated with carcinoid syndrome.

Elevated levels of 5-HIAA, a by-product produced when serotonin breaks down in the body, can be detected from a urine sample. Serotonin is one of the key body chemicals released by carcinoid tumors that are associated with carcinoid syndrome. The test can positively detect carcinoid tumors 73% of the time, and is generally regarded as an accurate test. However, the level of 5-HIAA only becomes elevated when carcinoid tumors have metastasized to the liver, making the potential for a cure less likely. 5-HIAA testing is useful to estimate the extent of disease and survival.

Update/Pins and Needles!

by gr8gatsb

Just have to share:
Saw the doc today for follow-up after the weekend of rest/monitoring for pre-eclampsia.
Good news, blood pressure is down.
Bad news, there's still protein in my urine and my platelets are low. The full labs aren't back yet and I'm on pins and needles awaiting the official diagnosis.
Crazy news, if they diagnose me with pre-e, we'll be meeting this baby within a week!!!
Oh my gosh!!! :)

I gained 30 lbs in 10 days

by soyyo

Really, even the doctors couldn't believe it. That's when I realized I had pre-eclampsia, my blood pressure had started its climb a couple of weeks before and I had had a little protein in my urine, but the weight gain was what sealed the diagnosis.
But you can have water retention without pre-eclampsia. How is your blood pressure?
I didn't do anything but bear it - I had to give birth about 2 weeks later.

Hi thanks - I have been trying to get diagnosis

by and--

The doctors do not seem to be listening or care. My boss sent me to the er last monday and I had shooting pains ( sciatic down the whole left side of my body along with numbness in 2 areas and my leg didn't want to work - they didn't even really check me out they tested me for numbness in an unaffected part of my leg ( and ignored me when I said so) gave me a shot that lasted an hour and requested a urine sample which they never cam eback to test qand sent me on my way. @ days later saw orthopedist that also ignored symptoms and decided at 34 years old I must have arthritis ( the only kind I could have is rehumatoid and my symptoms do not even match that) He is demanding a blood test for that but never schedualed it with me

Well the origional diagnosis was a virus

by -

That's after she spiked a fever OVER 105 and was vomiting. When we took her back in because we couldn't get the fever down they did a urine test and found she had a bad UTI.
She had been in and out of the doctors since October for a stomach ache but they couldn't find anything (altho they never did blood or urine tests) and suggested that it was an attention getting thing and to ignore it.
So now they are saying it most likely was the UTI all along and the preliminary tests showed white and red blood cells in her urine, and indicated it may have affected her kidneys

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